Autophagy controls centrosome number by degrading Cep63
نویسندگان
چکیده
Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin-proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62-/- mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63.
منابع مشابه
Autophagy controls centrosome number
It is believed that the number of centrosomes in a cell is tightly regulated by the degradation of centrosomal proteins via the ubiquitin–proteasome protein degradation system. However, we recently demonstrated that autophagy also participates in the regulation of centrosome number. The centrosome is the major component of the microtubule organizing center of mammalian cells, and plays an essen...
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